IZotope Dialogue Match 1.0.2 X64


IZotope Dialogue Match 1.0.2 X64

Non-selective non-steroidal anti-inflammatory drugs

Non-selective non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat osteoarthritis. In particular, non-selective NSAIDs are used at low daily dosage and over longer time periods (12 weeks) to reduce pain and inflammation and, thus, joint stiffness. As in the case of selective COX-2 inhibitors, it is considered that part of the analgesic effect is mediated via the reduction of prostaglandin synthesis.

Recently, the cost-effectiveness of NSAIDs was evaluated by Wong et al. \[[@B92]\]. The treatment costs of an NSAID were compared to the costs of glucosamine and a cost-saving effect was found. However, according to the authors, the cost-effectiveness of glucosamine was much better than that of the NSAIDs.

Besides the cost-effectiveness, there is a problem that NSAIDs might have side-effects, such as gastric irritation, flushing, decreased renal function and cardiovascular side-effects \[[@B93]\].

In clinical research on the effectiveness of non-selective NSAIDs, de Wilde et al. \[[@B94]\] examined the effectiveness of an NSAID versus a placebo in the treatment of OA patients. During a period of 3 months, patients had 5 weekly study visits and they were randomized to receive a placebo or rofecoxib (50 mg/day). At the end of this period the patients in the placebo group received treatment and the patients who were on rofecoxib were asked to stop the drug

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