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An ultrasound assisted electrospinning method was used to produce porous fibrous scaffolds from bovine tendon. A range of electrospinning parameters were investigated and the structure and mechanical properties of electrospun scaffolds were analyzed. The scaffolds were characterized using the porosity, water absorption, mechanical strength, and the effects of surface morphology. The best average porosity, mechanical properties, and pore size distribution were obtained for the scaffolds prepared with a 5% weight ratio of hydrophobic glycolide and 85% weight ratio of hydrophilic poly-ethylene glycol. Moreover, the deformation of the scaffolds after the compression test was higher than that of the control scaffold. These scaffolds had a good structural integrity. The ultrasound time and needle diameter did not have any significant effects on the scaffold structure, except for the the pore size.[Chemotherapy for advanced lung cancer: a 2-year evaluation].
Fourteen patients with inoperable or recurrent lung cancer were treated with a combination of cyclophosphamide and adriamycin. The dose of cyclophosphamide was 500 mg/m2 and that of adriamycin was 50 mg/m2. All patients were assessed at the end of 2 years from the beginning of the treatment. The response rate was 57.1% and the median survival time was 48.5 weeks. The best results were noted in patients with bulky tumor and good performance status. Our results suggest that a combination of cyclophosphamide and adriamycin could be a useful regimen for patients with advanced lung cancer.Upsides and Downgrades

UBS downgraded its rating on Transocean (NYSE:RIG) to Underweight from Equal Weight with a price target of $24.00, which implies a projected compound annual growth rate (CAGR) of -0.9%. UBS also sees the stock trading below its intrinsic value of $20.00 based on the company’s market capitalization and marginal profit growth.

Transocean currently has an average rating of Hold and an average target price of $25.91,

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